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Depletion or inhibition of GPX4 increases sensitivity to palbociclib and giredestrant, and their combination, in ER+ breast cancer models, with GPX4 null xenografts being highly sensitive to palbociclib
As well, NAC supplementation increased levels of GSH in individuals with low GSH levels and improved redox homoeostasis (Reference Paschalis, Theodorou and Margaritelis48)
doi: 10.1016/j.coi.2017.04.004 81 MihaylovaMMShawRJ
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